|  |  | High TRAIL-R1 | Low TRAIL-R1 | p value | ||
---|---|---|---|---|---|---|---|
 | N | % | N | % | N | % |  |
Total Number of Cases | 387 | Â | 331 | 85.5 | 56 | 14.5 | Â |
Age | Â | Â | Â | Â | Â | Â | Â |
   < = 50 years | 126 | 32.6 | 110 | 87.3 | 16 | 12.7 | 0.4870 |
   > 50 years | 261 | 67.4 | 221 | 84.7 | 40 | 15.3 |  |
Gender | Â | Â | Â | Â | Â | Â | Â |
   Male | 193 | 49.9 | 167 | 86.5 | 26 | 13.5 | 0.5773 |
   Female | 194 | 50.1 | 164 | 84.5 | 30 | 15.5 |  |
Tumour Site | Â | Â | Â | Â | Â | Â | Â |
   Left colon | 324 | 83.7 | 276 | 85.2 | 48 | 14.8 | 0.6576 |
   Right colon | 63 | 16.3 | 55 | 87.3 | 8 | 12.7 |  |
Histological Type | Â | Â | Â | Â | Â | Â | Â |
   Adenocarcinoma | 334 | 86.3 | 291 | 87.1 | 43 | 12.9 | 0.0355 |
   Mucinous Carcinoma | 53 | 13.7 | 40 | 75.5 | 13 | 24.5 |  |
Tumour Stage | Â | Â | Â | Â | Â | Â | Â |
   I | 55 | 15.0 | 53 | 96.4 | 2 | 3.6 | 0.0251 |
   II | 126 | 34.2 | 105 | 83.3 | 21 | 16.7 |  |
   III | 141 | 38.3 | 121 | 85.8 | 20 | 14.2 |  |
   IV | 46 | 12.5 | 36 | 78.3 | 10 | 21.7 |  |
Differentiation | Â | Â | Â | Â | Â | Â | Â |
   Well | 33 | 8.5 | 30 | 90.9 | 3 | 9.1 | 0.0887 |
   Moderate | 284 | 73.4 | 247 | 87.0 | 37 | 13.0 |  |
   Poor | 70 | 18.1 | 54 | 77.1 | 16 | 22.9 |  |
KRAS Mutation | Â | Â | Â | Â | Â | Â | Â |
   Present | 75 | 28.3 | 67 | 89.3 | 8 | 10.7 | 0.7407 |
   Absent | 190 | 71.7 | 167 | 87.9 | 23 | 12.1 |  |
K-RAS 2A | Â | Â | Â | Â | Â | Â | Â |
   High expression | 155 | 46.7 | 150 | 96.8 | 5 | 3.2 | < 0.0001 |
   Low expression | 177 | 53.3 | 142 | 80.2 | 35 | 19.8 |  |
Cleaved-Caspase 3 | Â | Â | Â | Â | Â | Â | Â |
   High expression | 172 | 49.9 | 160 | 93.0 | 12 | 7.0 | 0.0011 |
   Low expression | 173 | 50.1 | 141 | 81.5 | 32 | 18.5 |  |
P27 (Nuc) | Â | Â | Â | Â | Â | Â | Â |
   High expression | 139 | 38.4 | 130 | 93.5 | 9 | 6.5 | 0.0024 |
   Low expression | 223 | 61.6 | 185 | 83.0 | 38 | 17.0 |  |
MSI-Molecular | Â | Â | Â | Â | Â | Â | Â |
   MSI-H | 67 | 18.7 | 56 | 83.6 | 11 | 16.4 | 0.4731 |
   MSI-S/L | 292 | 81.3 | 254 | 87.0 | 38 | 13.0 |  |
Overall Survival | Â | Â | Â | Â | Â | Â | Â |
   5 Years |  |  |  | 68.1 |  | 53.9 | 0.0124 |