Figure 5From: Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikisTM treatment significantly inhibits oral squamous cell invasiveness. TM effect on tumor cell invasiveness was examined by Matrigel invasion assay. A; representative photomicrographs of invaded cells with (TM+) or without TM (TM-) treatment.B; number of tumor cells that had invaded through the Matrigel were counted in 5 high power fields. *, represents a significant difference (p < 0.05) as compared to the control group. C; Culture supernatants from OSCC-3 cells co-cultured with EC-Bcl-2 or EC-VC were resolved using 10% polyacrylamide gelatin gels. After electrophoresis, the gels were developed and stained by 0.5% Coomassie Brilliant Blue R-250 solution to visualize the bands. D; the band density was measured and expressed as average band density. *, represents a significant difference (p < 0.05) as compared to the OSCC-3-EC-VC group and **, represents a significant difference (p < 0.05) as compared to the OSCC-3-EC-Bcl-2 group.Back to article page