Figure 6

Antitumor efficacy of CA-074 in human melanoma xenografts. (A) Tumor growth curves of mice bearing MM1 melanoma cells and treated i.v. with vehicle alone (υ) or with CA-074 (σ) for eight consecutive days, starting from day 6 after cell injection. Mean tumor weights in mg ± SD are shown. (B) Mice were injected i.v. with MM4 cells and the day after, treated with CA-074 for eight consecutive days. At day 14 after cells injection, lungs were removed and fixed in Bouin's solution to distinguish tumor nodules from lung tissue, and the number of metastases was evaluated. The boxes show medians and 75th and 25th percentiles of the data, while the whiskers indicate the minimum and maximum values. (C) Representative images of metastatic nodules in lungs from control and treated mice. Note the lower number of nodules in the right picture.