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Figure 4 | Molecular Cancer

Figure 4

From: R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair

Figure 4

Roscovitine inhibits NHEJ activity synergistically when combined with Doxorubicin treatment in A549 cells. A) Analysis by real time PCR of NHEJ plasmid re-ligation activity of untreated A549 cell lysate with the addition of 20 μM Roscovitine, DMSO or Wortmannin. B) Analysis by real time PCR of NHEJ plasmid re-ligation activity in A549 cells treated for 12 hours with 20 μM Roscovitine. Wortmannin was added to untreated cell lysate as a negative control for NHEJ activity in vitro.

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Molecular Cancer

ISSN: 1476-4598