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Table 1 Statistically significant genes involved in DDR after combination treatment

From: R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair

ID
AFFYMETRIX
Gene
symbol
A549 D1 A549 D2 A549
DR1
A549
DR2
M P.Value
Signal
223598_at RAD23B 8.83 8.91 7.68 7.88 -1.09 0.000223
202996_at POLD4 10.01 10.14 8.89 9.29 -0.98 0.001349
209084_s_at RFC1 5.67 5.77 4.87 4.76 -0.90 0.000436
219418_at NHEJ1 6.76 6.55 5.75 5.96 -0.80 0.001689
211450_s_at MSH6 8.46 8.47 7.61 7.76 -0.78 0.001138
209349_at RAD50 6.40 6.48 5.63 5.75 -0.75 0.001394
203720_s_at ERCC1 9.57 9.65 8.78 8.98 -0.73 0.002189
205887_x_at MSH3 5.71 5.56 5.03 4.85 -0.69 0.003738
219715_s_at TDP1 7.94 7.81 7.26 7.12 -0.68 0.002669
210543_s_at PRKDC 8.36 8.36 7.78 7.72 -0.61 0.00473
208643_s_at XRCC5(Ku80) 9.94 10.06 9.31 9.46 -0.61 0.00434
213734_at RFC5 7.64 7.37 6.91 7.03 -0.53 0.014248
212525_s_at H2AFX 6.05 6.17 5.51 5.69 -0.51 0.011937
211851_x_at BRCA1 5.84 5.93 5.39 5.46 -0.46 0.022329
204752_x_at PARP2 7.89 7.95 7.50 7.65 -0.34 0.049
205672_at XPA 7.63 7.54 7.89 7.87 0.29 0.03678
221143_at RPA4 3.79 4.06 4.25 4.26 0.33 0.01878
1053_at RFC2 6.83 6.61 7.05 7.07 0.34 0.049
227766_at LIG4 5.56 5.40 6.11 5.88 0.52 0.025825
202176_at ERCC3 7.84 7.70 8.31 8.30 0.54 0.006878
209903_s_at ATR 8.11 7.93 8.64 8.53 0.57 0.009919
202451_at GTF2H1 8.60 8.55 9.29 9.07 0.61 0.01218
232134_at POLS 6.32 6.00 6.98 6.75 0.71 0.008367
231119_at RFC3 4.31 4.56 4.95 5.35 0.72 0.008497
204023_at RFC4 7.26 7.17 8.04 7.84 0.72 0.00282
222233_s_at DCLRE1C 5.50 5.44 6.41 6.10 0.78 0.00239
213468_at ERCC2 5.82 5.85 6.58 6.64 0.78 0.000828
209805_at PMS2 6.67 6.74 7.56 7.43 0.79 0.000908
209805_at PMS2 6.67 6.74 7.56 7.43 0.79 0.000908
1554743_x_at PMS1 4.32 4.51 5.29 5.16 0.81 0.002444
204838_s_at MLH3 7.13 7.05 7.97 7.86 0.83 0.001711
  1. Genes involved in DNA repair mechanisms, those shown either decreased or increased in expression level (p value ≤ 0.05) after combination treatment with 1 μM Doxorubicin and 20 μM Roscovitine as compared to 1 μM Doxorubicin only, in A549 cells after 24 hours of treatment.