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Table 1 Statistically significant genes involved in DDR after combination treatment

From: R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair

ID

AFFYMETRIX

Gene

symbol

A549 D1

A549 D2

A549

DR1

A549

DR2

M

P.Value

Signal

223598_at

RAD23B

8.83

8.91

7.68

7.88

-1.09

0.000223

202996_at

POLD4

10.01

10.14

8.89

9.29

-0.98

0.001349

209084_s_at

RFC1

5.67

5.77

4.87

4.76

-0.90

0.000436

219418_at

NHEJ1

6.76

6.55

5.75

5.96

-0.80

0.001689

211450_s_at

MSH6

8.46

8.47

7.61

7.76

-0.78

0.001138

209349_at

RAD50

6.40

6.48

5.63

5.75

-0.75

0.001394

203720_s_at

ERCC1

9.57

9.65

8.78

8.98

-0.73

0.002189

205887_x_at

MSH3

5.71

5.56

5.03

4.85

-0.69

0.003738

219715_s_at

TDP1

7.94

7.81

7.26

7.12

-0.68

0.002669

210543_s_at

PRKDC

8.36

8.36

7.78

7.72

-0.61

0.00473

208643_s_at

XRCC5(Ku80)

9.94

10.06

9.31

9.46

-0.61

0.00434

213734_at

RFC5

7.64

7.37

6.91

7.03

-0.53

0.014248

212525_s_at

H2AFX

6.05

6.17

5.51

5.69

-0.51

0.011937

211851_x_at

BRCA1

5.84

5.93

5.39

5.46

-0.46

0.022329

204752_x_at

PARP2

7.89

7.95

7.50

7.65

-0.34

0.049

205672_at

XPA

7.63

7.54

7.89

7.87

0.29

0.03678

221143_at

RPA4

3.79

4.06

4.25

4.26

0.33

0.01878

1053_at

RFC2

6.83

6.61

7.05

7.07

0.34

0.049

227766_at

LIG4

5.56

5.40

6.11

5.88

0.52

0.025825

202176_at

ERCC3

7.84

7.70

8.31

8.30

0.54

0.006878

209903_s_at

ATR

8.11

7.93

8.64

8.53

0.57

0.009919

202451_at

GTF2H1

8.60

8.55

9.29

9.07

0.61

0.01218

232134_at

POLS

6.32

6.00

6.98

6.75

0.71

0.008367

231119_at

RFC3

4.31

4.56

4.95

5.35

0.72

0.008497

204023_at

RFC4

7.26

7.17

8.04

7.84

0.72

0.00282

222233_s_at

DCLRE1C

5.50

5.44

6.41

6.10

0.78

0.00239

213468_at

ERCC2

5.82

5.85

6.58

6.64

0.78

0.000828

209805_at

PMS2

6.67

6.74

7.56

7.43

0.79

0.000908

209805_at

PMS2

6.67

6.74

7.56

7.43

0.79

0.000908

1554743_x_at

PMS1

4.32

4.51

5.29

5.16

0.81

0.002444

204838_s_at

MLH3

7.13

7.05

7.97

7.86

0.83

0.001711

  1. Genes involved in DNA repair mechanisms, those shown either decreased or increased in expression level (p value ≤ 0.05) after combination treatment with 1 μM Doxorubicin and 20 μM Roscovitine as compared to 1 μM Doxorubicin only, in A549 cells after 24 hours of treatment.