Figure 7
From: The Wnt/β-catenin pathway regulates growth and maintenance of colonospheres
Downregulation of β-catenin inhibits transcriptional activity of TCF/LEF in parental colon cancer cells and the corresponding spheroids/colonospheres. TCF/LEF transcription activity in HCT-116 wt parental and colonosphere-derived cells is downregulated in the corresponding β-catenin transfected cells. *p < 0.001, compared to the corresponding vector-treated controls