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Table 1 Comparison of clinical features between breast tumors associated or not with L3MBTL4 loss (determined by aCGH)

From: Loss, mutation and deregulation of L3MBTL4 in breast cancers

Characteristics (N)

L3MBTL4 non deleted

L3MBTL4 deleted

p

odds ratio

 

N = 230

N = 77

  

Age (300)

52 (22-84)

51 (24-82)

0.69

 

Histological type (255)

  

0.57

 

Ductal

152 (78%)

48 (79%)

  

Lobular

15 (8%)

5 (8%)

  

Medularry

12 (6%)

2 (3%)

  

Mixt

8 (4%)

3 (5%)

  

Other

7(4%)

3 (5%)

  

Clinical form (301)

  

0.11

1.76

IBC

33 (15%)

18 (23%)

 

(0.87-3.5)

Non IBC

191 (85%)

59 (77%)

  

Pathological tumor size (240)

  

0.052

 

pT1

45 (25%)

8 (14%)

  

pT2

95 (52%)

28 (48%)

  

pT3

42 (23%)

22 (38%)

  

Pathological axillary lymph node status (266)

  

1.02E-02

0.46

Negative

96 (48%)

20 (30%)

 

(0.24-0.85)

Positive

103 (52%)

47 (70%)

  

SBR grade (267)

  

1.15E-02

 

1

38 (19%)

3 (5%)

  

2

63 (31%)

25 (38%)

  

3

100 (50%)

38 (58%)

  

ER (275)

  

0.11

0.6

Negative

84 (40%)

19 (29%)

 

(0.31-1.13)

Positive

125 (60%)

47 (71%)

  

PR (264)

  

0.32

0.74

Negative

96 (48%)

26 (41%)

 

(0.4-1.36)

Positive

104 (52%)

38 (59%)

  

P53 (192)

  

0.39

1.38

Negative

87 (59%)

30 (67%)

 

(0.65-3)

Positive

60 (41%)

15 (33%)

  

Ki67 (217)

  

0.23

0.64

Negative

53 (32%)

12 (23%)

 

(0.28-1.36)

Positive

112 (68%)

40 (77%)

  

ERBB2 (226)

  

1

1.03

Negative

145 (85%)

48 (86%)

 

(0.42-2.83)

Positive

25 (15%)

8 (14%)

  

Molecular subtype (264)

  

8.04E-04

 

Basal

63 (33%)

17 (23%)

  

ERBB2

22 (12%)

9 (12%)

  

Luminal A

52 (27%)

18 (25%)

  

Luminal B

29 (15%)

27 (37%)

  

Normal-like

25 (13%)

2 (3%)

  

Metastatic relapse (198)

  

0.32

0.62

no

135 (88%)

37 (82%)

 

(0.23-1.78)

yes

18 (12%)

8 (18%)

  

Death from breast cancer (239)

  

0.38

0.73

no

139 (77%)

41 (71%)

 

(0.36-1.52)

yes

42 (23%)

17 (29%)

  

5 year-Metastasis-free survival (198)

90%

81%

0.254

 

5 year-Overall specific survival (239)

78%

73%

0.271

 
  1. Note: IBC, Inflammatory Breast Cancer; SBR, Scarf-Bloom-Richardson, histological grade.