Table 2 Summary of L3MBTL4 alterations
From: Loss, mutation and deregulation of L3MBTL4 in breast cancers
Samples | Loss | Mutation | Loss and mutation | Breakages | *mRNA downregulation |
|---|---|---|---|---|---|
Total tumors (N = 307; *229) | 77 | 7(/180 studied) | 2 | 1 | 166 |
Luminal A (N = 70; *66) | 18 | 1 | 0 | Â | 62 |
Luminal B (N = 56; *47) | 27 | 1 | 0 | 1(T50115) | 45 |
ERBB2 (N = 31; *23) | 9 | 2 | 1 | Â | 22 |
Basal (N = 80; *67) | 17 | 1 | 1 | Â | 16 |
Normal-like (N = 27; *26) | 2 | 0 | 0 | Â | 21 |
Not informed (N = 43) | 4 | 2 | 0 | Â | 0 |
Total cell lines (N = 47) | 19 | 1 | 1 | 2 | Not applicable |
Luminal cell lines(N = 17) | 12 | 1 | 1 (BT-483) | 1 (MDA-MB-453) | Not applicable |
Basal cell lines (N = 9) | 2 | 0 | 0 | 1 (HCC38) | Not applicable |
Others/Not done (N = 21) | 5 | 0 | 0 | 0 | Not applicable |