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Figure 6 | Molecular Cancer

Figure 6

From: MiTF links Erk1/2 kinase and p21CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells

Figure 6

Distinct responses of MiTF to UVA and UVB radiation. A, NHMs were exposed to UVA (2.5 J/cm2) and collected for western blot at the indicated time points (top panel) or 4 hours post-UVA at various doses (bottom panel). The p53 serves as a positive control and p84 or α-tubulin serve as loading controls. B, NHMs were pre-treated with U0126 and then exposed to UVA and collected for western blot analysis at the indicated time points. C, No obvious Erk1/2 activation after UVA radiation. NHM was irradiated with either UVA (2.5 J/cm2) or UVC (3 mJ/cm2) and collected for western blot analysis 1 hour post-radiation. D, NHMs were exposed to UVB (25 mJ/cm2) and collected for western blot at the indicated time points (top panel) or 1 hour post-UVB at various doses (bottom panel). Again the p53 serves as a positive control and α-tubulin serve as a loading control.

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