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Figure 2 | Molecular Cancer

Figure 2

From: A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

Figure 2

FLLL32 inhibited STAT3 phosphorylation, and induced apoptosis in (A) SW480, (B) HCT-116 colorectal, (C) U87 glioblastoma, (D) U266 multiple myeloma, and (E) SNU449, (F) HEP3B liver cancer cells. Cells were treated with FLLL32 (2.5-10 μM) or curcumin (5-10 μM) of for 24 hours. Decreases in P-STAT3 by FLLL32 were associated with decreased STAT3 downstream target genes and increased cleavage of caspase-3 and PARP. The phosphorylation of ERK1/2 and/or mTOR was not obviously reduced.

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