A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

Table 1 Docking energies of curcumin and FLLL32 to STAT3

	Docking free energy (kcal/mol) to STAT3
Curcumin	-8.1(keto)
	no binding (enol)
FLLL32	-8.5

Curcumin has both enol and keto form. FLLL32 had better binding potency than curcumin.

ISSN: 1476-4598