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Figure 3 | Molecular Cancer

Figure 3

From: Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent

Figure 3

Curcumin inhibits nicotine-induced phosphorylation of Akt and over expression of COX-2 and Cyclin D1. (A-C) The cells were treated with various concentrations of nicotine (30 min for phospho-Akt and 24 h for COX-2 and Cyclin-D1) and whole cell lysates prepared were blotted against phospho-Akt, COX-2 and Cyclin-D1 antibodies. (D-F) The cells were treated with curcumin and then with nicotine (10-8 M in H1299 and 10-6 M in A549) and whole cell lysates were blotted as in (A-C). All blots are representative samples of three independent experiments.

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Molecular Cancer

ISSN: 1476-4598