Figure 4From: Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independentNicotine-induced over expression of IAPs and Bcl2 is inhibited by curcumin. (A-D) The cells were treated with nicotine for 24 h and whole cell lysates were Western blotted using antibodies against XIAP, cIAP-1 survivin and Bcl2. (E-H) The cells were treated with curcumin and then with nicotine (10-8M for H1299 and 10-6 M for A549) and whole cell lysates were blotted as in (A-D). All blots are representative samples of three independent experiments.Back to article page