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Figure 7 | Molecular Cancer

Figure 7

From: Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent

Figure 7

Curcumin inhibits enhancement of clonogenicity by nicotine, which induces p53 and p21 in A549 and p21 in H1299-p53 WT. (A-B) The cells were treated with nicotine and/or curcumin for 72 h, after which cells were split and seeded in six well plates, kept for 2 weeks and clones developed were stained and counted. (C-E) The cells were treated with nicotine (10-9-10-2M) for 24 h and whole cell lysates were Western blotted against p53 antibody. All figures are representative samples of three independent experiments.

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Molecular Cancer

ISSN: 1476-4598