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Figure 6 | Molecular Cancer

Figure 6

From: I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma

Figure 6

IKKβ inhibition in combination with Vincristine reduces p65 nuclear translocation and induces apoptosis. WSU-FSCCL cells were incubated with ML120B or Vincristine alone, or pretreated with ML120B (60 minutes) then cultured with Vincristine at indicated concentrations for 24 h. Total cell lysates were subjected to Western blot for detection of indicated protein using actin as a loading control. Nuclear and cytosolic p65 protein fractions were extracted from total cell lysates. GAPDH is used as a cytosolic loading control.

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