Figure 8

In vivo activity of ML120B alone, and with CHOP in WSU-DLCL2-SCID xenograft mouse model, tumor weights represent Mean and standard error of mean (SEM). A. Activity of ML120B as single agent: WSU-DLCL₂ tumors were xenografted s.c. into 10 ICR SCID mice/group on day 0 and dosing was initiated on day 7. ML120B was administered p.o. 120 mg/kg one dose on day 7 (× 1), 60 mg/kg twice (BID) on day 7 (× 2), and 60 mg/kg BID for 28 days starting on day 7 (× 28). Each point represents mean tumor weight of animal in each group ± SEM. B. ML120B plus CHOP treatment: Xenografts were developed as in A and treatment started on day 7. CHOP was administered at maximum tolerated doses (MTD) as previously defined (see Material and Methods), ML120B was administered p.o. 60 mg/kg BID for 28 days (as in A), ML120B in combination with CHOP at MTD.