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Figure 4 | Molecular Cancer

Figure 4

From: MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma

Figure 4

Knock-down of miR-221/222 inhibits tumor growth in a xenograft mouse model. (A) When subcutaneous tumors were established, As-miR-221/222 were injected in a multi-site injection manner every 3 days for 15 days. Tumor volumes were measured every 2 days during treatment. (B) TUNEL assay in xenograft tumor sections revealed that As-miR-221/222 induced cell apoptosis. (C) Ki-67 expression was detected by immunohistochemistry assay in xenograft tumor sections. (D) Fluorescence in situ hybridization showed that As-miR-221/222 effectively inhibited the expression of miR-221 and miR-222. (E-G) PUMA, Bax and Bcl2 expression was detected by immunohistochemistry assay in xenograft tumor sections. * P < 0.05 compared with control group.

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