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Figure 3 | Molecular Cancer

Figure 3

From: Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases

Figure 3

Importance of hsa-miR-27a in oncogenesis, proliferation and differentiation. miR-27a induces oncogenesis by negatively regulating FOXO1 (transcription factor that regulates genes involved in apoptosis and cell cycle progression), RYBP (pro-apoptotic gene) and ZBTB10 (repressor of Sp proteins which are known to cause proliferative and angiogenic phenotype in cancer cells), mediates differentiation by down regulating RUNX1 (regulator of haematopoesis) and PPARĪ³ and also promotes proliferation by targeting RYBP (pro-apoptotic gene).

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