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Figure 8 | Molecular Cancer

Figure 8

From: Coordination of glioblastoma cell motility by PKCι

Figure 8

Model for the role of PKCι in lamellipod formation. An initial complex of the scaffolding protein Par6, PKCι and Lgl forms at the plasma membrane. Lgl is in its active form and binds non-muscle myosin IIA. PKCι then phosphorylates and inactivates Lgl. Uncoupling of Lgl from non-muscle myosin IIA then allows the actin remodeling required for lamellipod formation. In the absence of Lgl inactivation by PKCι, lamellipod formation is aborted and cells attempt to form lamellipodia at alternate sites.

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