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Table 3 Summary of the most relevant gene sets enriched in responders and non-responders to radiotherapy

From: An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients

Gene sets most significantly enriched in responders

BH adjusted

p-value

Gene sets most significantly enriched in non-responders

BH adjusted p-value

Murat et al. immune gene cluster (G24)

< 10-4

MSigDB C2 pathways MENSE_HYPOXIA_UP

< 10-4

GO:0042613 - MHC class II protein complex

< 10-4

SMD processes core_hypoxia1_sw

< 10-4

SMD cancerModules Immune (humoral) and inflammatory response

< 10-4

MSigDB C2 pathways HYPOXIA_REVIEW

0.001

GO:0006955 - immune response

< 10-4

SMD cancerModules DRG (dorsal root ganglia) genes

0.006

MSigDB C2 pathways LEE_TCELLS2_UP

< 10-4

MSigDB C2 pathways HYPOXIA_REG_UP

0.01

GO:0006954 - inflammatory response

< 10-4

  

GO:0045087 - innate immune response

< 10-4

  
  1. Summary of gene sets analysis using KEGG, Biocarta pathways, Gene Ontology (GO) terms, Molecular Signatures Database (MSigDB) gene sets, Stanford microarray database (SMS) and Murat et al.'s gene sets [12]. BH: Benjamini and Hochberg.
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Molecular Cancer

ISSN: 1476-4598