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Figure 5 | Molecular Cancer

Figure 5

From: ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis

Figure 5

Metastasis was observed after injection of RM11A variants. H&E stained sections of lung tissue with metastasis following intra-mammary injection and subsequent mammary tumor development of RM11A+Dox (b) or RM11A+Dox/ErbB2 injected mice (a) are shown (arrows). Typically these lesions were relatively small. Metastasis was also observed to occur following IGF-IR downregulation in RM11A+Dox/ErbB2-injected animals and these lesions were usually larger than aforementioned lesions (c, d); (LM = lung metastasis; NL = normal lung). Scale bars: 100 μm. Western blotting was performed on protein lysates from RM11A+Dox and RM11A+Dox/ErbB2 doxycycline-independent recurrent tumors and metastases to confirm IGF-IR and ErbB2 levels (e). Relative quantification is shown in (f).

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