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Table 4 Summary of metastasis in FVB mice injected with RM11A-ErbB2 stable transfectants

From: ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis

 

RM11A+Dox

RM11A+Dox/ErbB2

RM11A+Dox after IGF-IR suppression

RM11A+Dox/-ErbB2 after IGF-IR suppression

Number of mice

21

19

12

13

Number with microscopic lung metastasis

3

2

0

6

Percent with metastasis

14.3

10.5

0.0

46.2a

Number of mice with macroscopic lung metastasis

0

0

0

3

Number of mice with macroscopic liver metastasis

0

0

0

1

  1. a Significantly different than RM11A+Dox after IGF-IR suppression (p < 0.05)
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Molecular Cancer

ISSN: 1476-4598