Convergence between Wnt and EGFR pathways. Wnt binds to Frizzled. Frizzled transactivates EGFR signaling by matrix metalloproteinase-mediated release of soluble EGFR ligands. Upon activation, EGFR could transactivate β-catenin, possibly through receptor tyrosine kinase-PI3K/Akt pathway, and β-catenin might also form heterodimer with EGFR and activate EGFR pathway. NKD2 binds to TGFα and escorts it to the plasma membrane, where TGFα gets released, and then NKD2 binds to Dvl-1 and targets it for mutual degradation, thus maintains the epithelial cell homeostasis.