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Figure 8 | Molecular Cancer

Figure 8

From: Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors

Figure 8

EBNA1 expression leads to increased levels of EBER expression. RT-PCR assay for (a) tRNATyr and EBER expression in response to transient expression of increasing amounts of EBNA1 in the EBER-expressing cell line Ad/AH-EBERs. The experiments were conducted in biological triplicate. Numbers below the bands in the EBER1, EBER2 and tRNA rows represent the mean fold increase (± SD) in expression between the EBNA1-positive cells and the control as assessed by densitometry. (b) RT-PCR comparing EBER and EBNA1 expression in AdAH cell lines with levels seen in the Burkitt's lymphoma-derived cell line, Namalwa. (c) EBER expression in Ad/AH-rEBV cells transiently transfected with dominant negative EBNA1 vector or pSG5 control plasmid. Numbers to the right indicate the mean fold decrease (± SD) of EBER expression in triplicate experiments.

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Molecular Cancer

ISSN: 1476-4598