Skip to main content
Figure 2 | Molecular Cancer

Figure 2

From: Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma

Figure 2

LRP5/6, Krm1/2 and β-catenin gene expression of HMCLs, CD138+ primary myeloma cells and SCs from patients with MM and healthy donors. HMCLs include RPMI-8226, NCI-H929, LP-1, U266, CZ-1, KM-3 and Sko-007. B: CD138+ primary myeloma cells. C: SCs from patients with MM. D: SCs from healthy donors. LRP5/6 and Krm1/2 mRNA expression in SCs from patients with MM (C) were significantly higher than those in SCs from healthy donors (D) (p < 0.001) and those in CD138+ primary myeloma cells (B) (p < 0.01). β-catenin mRNA expression in HMCLs and CD138+ primary myeloma cells was obviously higher than those in SCs from patients with MM and healthy donors (p < 0.05). There was no significant differences in the β-catenin mRNA expression levels between SCs from healthy donors and those from patients with MM (p > 0.05).

Back to article page