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Table 1 CXCL12-mediated inhibition of tumor growth in different strains of mice

From: Multiple functions of CXCL12 in a syngeneic model of breast cancer

Strain

Experiment

Day terminated

Mean tumor weight (g) ± SEM (n)

p value (t test)

4TX12 tumor weight as% of control

   

4T12Ala

4TX12

  

Wild type

1

33

0.83 ± 0.06 (12)

0.20 ± 0.04 (12)

***, <0.0001

24.2

 

2

27

0.90 ± 0.13 (5)

0.21 ± 0.07 (6)

***, 0.0008

22.9

SCID

1

19

0.56 ± 0.11 (5)

0.60 ± 0.02 (5)

ns, 0.7426

106.6

 

2

23

0.79 ± 0.08 (5)

0.76 ± 0.06 (5)

ns, 0.7236

95.4

pfp-/-

1

28

0.79 ± 0.10 (6)

0.49 ± 0.05 (6)

*, 0.0232

61.4

TRAIL-/-

1

28

0.78 ± 0.14 (7)

0.44 ± 0.03 (7)

*, 0.0369

57.1

IFN-γ-/-

1

28

1.21 ± 0.17 (7)

0.64 ± 0.18 (7)

*, 0.0403

52.9

  1. ns, not significant.