Table 1 Important findings regarding expression of Sema4D and Plexin-B1 in various human cancers
Cancer Type | Findings | Prognosis |
|---|---|---|
Soft tissue sarcomas[30] | Higher Sema4D expression was associated with higher mitotic counts, cellularity, necrotic ratio and Ki-67 index | Poorer overall survival and disease-free survival with higher Sema4D expression |
B-cell chronic lymphocytic leukemia[43] | Sema4D-expressing CD38+ B-CLL cells showed increased proliferation and survival. | Not available |
Lower Plexin-B1 was associated with a higher histologic grade, proliferative index and ErbB-2 expression in estrogen receptor-positive cases | Poorer disease-free survival with lower Plexin-B1 expression in estrogen receptor- positive cases | |
Renal cell carcinoma[46] | 81% of renal cell carcinoma lost the plexin-B1 expression | Not available |
Breast and Ovarian Carcinomas[47] | Co-expression of Plexin-B1 and Met resulted in Met activation and was associated with a higher tumor grade and lymph node metastasis | Not available |
Prostate adenocarcinoma [42] | Expression of Plexin-B1 and Sema4D was significantly correlated and both were highly expressed in cancer cases (77% and 58% respectively) | Not available |