MicroRNA roles in beta-catenin pathway

Table 1 Novel modulators of Wnt/β-catenin signaling pathway

upstream regulators	function	coregulators	function	downstream targets	transcription
EGFR [20, 21]	↑	CtBP [53]	↓	AKT1 [77]	→
AKT1 [26, 28]	↑	Groucho [52]	↓	STAT3 [86, 87]	→
miR-135a/b [50]	↑	HDAC1/2 [61, 62]	↓	Gbx2 [82]	→
miR-315 [51]	↑	KLF4 [72]	↓	MMP1 [20]	→
JNK [34, 35]	↑ or ↓	MAD2B [73]	↓	Foxc1 [84]	→
miR-200a [36, 42]	↓	VentX [74]	↓	StarD7 [85]	→
miR-21 [43]	↓	HDAC3/6 [64, 65]	↑	E2F1 [87]	←
miR-203 [48]	↓	c-Jun [66]	↑	p16INK4a [83]	←
miR-8 [49]	↓	TNIK [70]	↑	miR-15/16 [93]	←
		Snail [71]	↑	miR-122a [94]	←
				miR-375 [95]	←

ISSN: 1476-4598