TY - JOUR AU - Cubas, Rafael AU - Zhang, Sheng AU - Li, Min AU - Chen, Changyi AU - Yao, Qizhi PY - 2010 DA - 2010/09/21 TI - Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway JO - Molecular Cancer SP - 253 VL - 9 IS - 1 AB - Trop2 is a cell-surface glycoprotein overexpressed by a variety of epithelial carcinomas with reported low to restricted expression in normal tissues. Expression of Trop2 has been associated with increased tumor aggressiveness, metastasis and decreased patient survival, but the signaling mechanisms mediated by Trop2 are still unknown. Here, we studied the effects murine Trop2 (mTrop2) exerted on tumor cellular functions and some of the signaling mechanisms activated by this oncogene. SN - 1476-4598 UR - https://doi.org/10.1186/1476-4598-9-253 DO - 10.1186/1476-4598-9-253 ID - Cubas2010 ER -