Table 3 Transition features and the presumably regulated proteins

BJ → BJ-T

(hTERT)

prevention of senescence

ACTB, ANXA2, LDHB, M6PRBP1, NPM1, SERPINB2

PRDX6

BJ-T → BJ-TE

(SV40)

proliferation and prevention of apoptosis

HEXB, IL1B, MAPRE1, PCNA, PPME1, PSMA3, RANBP1, RPS3A, SLC25A24, TBCB, TRAP1

ACTB, AHCY, ALDH1A1, ANXA2, EIF4A1,

FAM129B, G6PD, GSN, HNRPH3, HSPB1,

IFIT2, ILF2, IMPDH2, IPI00410404,

KRT7, LAP3, LMNA, M6PRBP1, SFRS9,

MAP2K2, PACSIN2, PHGDH, PPME1, PRDX6,

PRPF19, SLC25A24, TARDBP, TBCE, TRAF5, VIM

BJ-TE → BJ-TER

(RAS)

prevention of anoikis and growth-factor indepandancy

ACTB, EIF4A1, HSP90AA1, HSP90AB1, ILF2, M6PRBP1

EEF1A1, ENO1