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Figure 3 | Molecular Cancer

Figure 3

From: Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition

Figure 3

Salirasib modulates the expression of cell cycle effectors and inhibitors. A. Representative Western blots after one and two days of treatment in the 3 cell lines. B-D. Quantification of the principal changes in protein expression by densitometry analysis (n = 6 per group) in HepG2 (B), Huh7 (C), and Hep3B (D) cells. E. Quantification of p21 mRNA expression by quantitative PCR after one day of treatment (n = 6 per group). Data are expressed as relative change versus control (DMSO) set arbitrarily at 1 (dotted line) and are presented as mean ± SEM. * P < 0.05, ** P < 0.01 and *** P < 0.001 in treated groups versus control group.

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