Figure 3From: Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibitionSalirasib modulates the expression of cell cycle effectors and inhibitors. A. Representative Western blots after one and two days of treatment in the 3 cell lines. B-D. Quantification of the principal changes in protein expression by densitometry analysis (n = 6 per group) in HepG2 (B), Huh7 (C), and Hep3B (D) cells. E. Quantification of p21 mRNA expression by quantitative PCR after one day of treatment (n = 6 per group). Data are expressed as relative change versus control (DMSO) set arbitrarily at 1 (dotted line) and are presented as mean ± SEM. * P < 0.05, ** P < 0.01 and *** P < 0.001 in treated groups versus control group.Back to article page