Molecular Cancer

Table 2 Summary of apoptosis-related changes

From: Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition

	HepG2	Huh7	Hep3B
Caspase-3/7	↑↑↑	--	↑↑
Cytochrome c	↑ (SA)	↑ (SA)	↑ (SA)
Mcl1	--	↓	↓
Bcl-X _L	--	--	--
Survivin	↓	↓	↓↓
cFLIP	--	↓↓	↓↓
DR4	↑↑	--	↑↑
DR5	↑↑	--	↑↑
TNFα	↓	--	↑↑↑
Fas	↑	NE	NE

--: no change; ↑(increase of 1-2x over controls)/↑↑(2-5x)/↑↑↑(>5x); ↓(reduction <2x compared to controls)/↓↓(reduction >2x compared to control); NE: not expressed; SA: subjective appraisal. Bold characters: anti-apoptotic. Plain characters: pro-apoptotic.

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