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Table 3 Top lists of activated kinases and pathways in different conditions

From: Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option

  top five activated kinases top activated signalling pathway
normal medium condition (including all kinases in the analysis) ck2a1 NF-kappaB
  lck Src
  fyn RAR
  fgr PPAR
normal medium condition (leaving out cell cycle related kinases in the analysis) ck2a1 NF-kappaB
  lck Src
  fyn RAR
  camk2b PPAR
starved medium condition mapk14 NF-kappaB
  ck2a1 RAR
  akt1 p53
  egfr G1/S transition of the cell cycle
  erbb2 oxidative stress response
  1. Whereas activated kinases differed between cells grown in normal medium (RMPI supplemented with 10% inactivated calf serum), top five of activated signaling pathways were identical. Results were identical for cell lines and primary cultures. Cell lines cultured in starved medium conditions revealed a different top list of both kinases and activated signaling pathways. However, in all three different conditions, NF-kappaB was the most activated signaling pathway identified.
  2. prkcd: protein kinase C, delta; mapk14: mitogen-activated protein kinase 14; egfr: epidermal growth factor receptor; erbb2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2