Table 1 Polycomb genes expression in normal brain and specific tumor histologies.
From: Clinical significance of Polycomb gene expression in brain tumors
PRC | GENE | Category 1 (up-regulated) | Category 2 (down- regulated) | P value |
|---|---|---|---|---|
1 | BMI1 | Normal Brain | Glioblastoma | 5.85 E-27 |
| Â | CBX2 | Neural Stem Cell | Glioblastoma | 4.4 E-13 |
| Â | CBX7 | Normal Brain | Glioblastoma | 2.2 E-27 |
| Â | Â | Ganglioneur-oma/-oblastoma | Neuroblastoma | 2.4 E-7 |
| Â | PCGF1 | Glioblastoma | Astrocytoma | 1.2 E-6 |
| Â | PCGF6 | Astrocytoma/Oligodendroglioma | Glioblastoma | 4.0 E-6 |
| Â | PHC2 | Astrocytoma/Glioblastoma | Oligodendroglioma | 1.4 E-7 |
| Â | YY1 | Anaplastic Oligoastrocytoma | Normal Brain | 1.23 E-5 |
| Â | Â | Medulloblastoma with Advanced Neural Differentiation | Other hystologies | 8.86 E-27 |
| Â | Â | Oligodendroglioma | Mixed Glioma | 3.83 E-6 |
2, 3, 4 | EZH2 | Anaplastic Oligodendroglioma | Normal Brain | 1,12E-12 |
| Â | Â | Anaplastic Astrocytoma | Normal Brain | 3,50E-13 |
| Â | Â | Glioblastoma | Normal Brain | 2,56E-23 |
| Â | Â | Neuroblastoma | Ganglioneur-oma/-oblastoma | 4,94E-08 |
| Â | Â | Glioblastoma | Astrocytoma/Ogligodendroglioma | 1.64 E-5 |
| Â | RBBP7 | Anaplastic Astrocytoma | Normal Brain | 6,0E-06 |
| Â | Â | Anaplastic Oligodenroglioma | Normal Brain | 5,60E-08 |
| Â | SUZ 12 | Anaplastic Oligodendroglioma | Normal Brain | 1.19 E-7 |
| Â | Â | Atypical Theratoid/Rhabdoid Tumor | Medulloblastoma | 5.50 E-8 |
4 | SIRT1 | Neural Stem Cell | Glioblastoma | 9.4 E-13 |
| Â | Â | Oligodendroglioma | Glioblastoma Astrocytoma | 1.9 E-11 |