Figure 3From: Mechanisms of transcriptional regulation and prognostic significance of activated leukocyte cell adhesion molecule in cancerALCAM promoter activity in melanoma tumor cells. A) Schematic diagram of DNA constructs used for reporter gene assays depicting truncations of the ALCAM promoter cloned upstream of a promoter-less luciferase (Luc) gene. Histogram shows the relative luciferase activity for each construct in melanoma cell lines. B) Schematic diagram as described above, and activity of the p1200ALCAMLuc construct containing a wild-type (filled circle) or mutant (open circle) consensus binding sequence for NF-κB in the ALCAM promoter.Back to article page