Figure 8

Anti-ALCAM antibodies reduce clustering of tumor cells circulating through the lung. A) (i) Medium power image of a rat lung section show MDA-MB-231 tumor cells logged in a medium-size vessel, ii) magnified section of the area enclosed by the dotted box in (i). B) Low-power image of rat lung section show MDA-MB-231 tumor cells in experiments with non-immune IgG (i) or anti-ALCAM antibody (ii). C) Number of tumor cells retained in isolated perfused rat lungs following incubations with non-immune IgG (n = 11) and Novocastra (n = 4) and GW (n = 7) monoclonal anti-ALCAM antibodies.