SerpinE2 gene expression is up-regulated in human colorectal tumors. Relative serpinE2 mRNA levels were determined by Q-PCR of human advanced adenomas and cancers compared to the adjacent healthy tissue (set at 1). mRNA levels were normalized to β2MIC mRNA levels. Data presented in are means ± SE of 5 to 19 biopsies per stage. *, significantly different from adjacent healthy tissue at p < 0.05 (Student's t test).