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Table 2 List of genes in the p53-p21 pathway upregulated following Sp1 knockdown

From: Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line

Probe Set ID Gene Title Gene Symbol 48 hr post Sp1 knockdown 72 hr post Sp1 knockdown
    Fold change Regulation Fold change Regulation
220403_s_at p53-regulated apoptosis-inducing protein 1 P53AIP1 2.76 up - No change
202627_s_at serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 SERPINE1 (PAI) 2.01 up 2.43 up
230330_at protein phosphatase 1D magnesium-dependent, delta isoform PPM1D (WIP-1) 1.86 up - No change
204566_at protein phosphatase 1D magnesium-dependent, delta isoform PPM1D (WIP-1) 1.72 up 1.52 up
202284_s_at cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A 1.84 up 1.96 up
1555186_at cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A - No change 1.25 up
203409_at damage-specific DNA binding protein 2, 48kDa (p48 subunit) DDB2 1.79 up - No change
204859_s_at apoptotic peptidase activating factor 1 APAF1 1.76 up - No change
218346_s_at sestrin 1 SESN1 1.74 up 1.56 up
204285_s_at phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 (NOXA) 1.48 up 1.60 up
204286_s_at phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 (NOXA) - No change 1.55 up
204781_s_at Fas (TNF receptor superfamily, member 6) FAS 1.73 up 1.59 up
215719_x_at Fas (TNF receptor superfamily, member 6) FAS 1.47 up 1.35 up
204780_s_at Fas (TNF receptor superfamily, member 6) FAS 1.43 up 1.45 up
216252_x_at Fas (TNF receptor superfamily, member 6) FAS 1.41 up - No change
208712_at cyclin D1 CCND1 1.46 up 1.39 up
208711_s_at cyclin D1 CCND1 1.34 up - No change
201700_at cyclin D3 CCND3 1.42 up - No change
222986_s_at scotin SCOTIN 1.40 up - No change
242899_at sestrin 3 sesn3 1.38 up - No change
241015_at sestrin3 sesn3 - No change 1.43 down
208796_s_at cyclin G1 CCNG1 1.38 up - No change
229415_at cytochrome c, somatic CYCS 1.35 up - No change
211711_s_at phosphatase and tensin homolog PTEN 1.25 up - No change
238075_at CHK1 Checkpoint homolog (S.Pombe) CHK1 1.23 up - No change
202981_x_at seven in absentia homolog 1 (Drosophila) SIAH1 1.20 up - No change
209260_at stratifin SFN (14-3-3σ) 1.33 up - No change
33323_r_at stratifin SFN (14-3-3σ) - No change 1.43 up
33322_i_at stratifin SFN (14-3-3σ) - No change 1.35 up
213523_at cyclin E1 CCNE1 - No change 1.34 up
204855_at serpin peptidase inhibitor, clade B (ovalbumin), member 5 SERPINB5 (Maspin) - No change 1.32 up
201110_s_at thrombospondin 1 THBS1 (TSP1) - No change 1.32 up
211692_s_at BCL2 binding component 3 BBC3 (PUMA) - No change 1.23 up