Table 2 List of genes in the p53-p21 pathway upregulated following Sp1 knockdown

220403_s_at

p53-regulated apoptosis-inducing protein 1

P53AIP1

2.76

up

-

No change

202627_s_at

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

SERPINE1 (PAI)

2.01

up

2.43

up

230330_at

protein phosphatase 1D magnesium-dependent, delta isoform

PPM1D (WIP-1)

1.86

up

-

No change

204566_at

protein phosphatase 1D magnesium-dependent, delta isoform

PPM1D (WIP-1)

1.72

up

1.52

up

202284_s_at

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

CDKN1A

1.84

up

1.96

up

1555186_at

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

CDKN1A

-

No change

1.25

up

203409_at

damage-specific DNA binding protein 2, 48kDa (p48 subunit)

DDB2

1.79

up

-

No change

204859_s_at

apoptotic peptidase activating factor 1

APAF1

1.76

up

-

No change

218346_s_at

sestrin 1

SESN1

1.74

up

1.56

up

204285_s_at

phorbol-12-myristate-13-acetate-induced protein 1

PMAIP1 (NOXA)

1.48

up

1.60

up

204286_s_at

phorbol-12-myristate-13-acetate-induced protein 1

PMAIP1 (NOXA)

-

No change

1.55

up

204781_s_at

Fas (TNF receptor superfamily, member 6)

FAS

1.73

up

1.59

up

215719_x_at

Fas (TNF receptor superfamily, member 6)

FAS

1.47

up

1.35

up

204780_s_at

Fas (TNF receptor superfamily, member 6)

FAS

1.43

up

1.45

up

216252_x_at

Fas (TNF receptor superfamily, member 6)

FAS

1.41

up

-

No change

208712_at

cyclin D1

CCND1

1.46

up

1.39

up

208711_s_at

cyclin D1

CCND1

1.34

up

-

No change

201700_at

cyclin D3

CCND3

1.42

up

-

No change

222986_s_at

scotin

SCOTIN

1.40

up

-

No change

242899_at

sestrin 3

sesn3

1.38

up

-

No change

241015_at

sestrin3

sesn3

-

No change

1.43

down

208796_s_at

cyclin G1

CCNG1

1.38

up

-

No change

229415_at

cytochrome c, somatic

CYCS

1.35

up

-

No change

211711_s_at

phosphatase and tensin homolog

PTEN

1.25

up

-

No change

238075_at

CHK1 Checkpoint homolog (S.Pombe)

CHK1

1.23

up

-

No change

202981_x_at

seven in absentia homolog 1 (Drosophila)

SIAH1

1.20

up

-

No change

209260_at

stratifin

SFN (14-3-3σ)

1.33

up

-

No change

33323_r_at

stratifin

SFN (14-3-3σ)

-

No change

1.43

up

33322_i_at

stratifin

SFN (14-3-3σ)

-

No change

1.35

up

213523_at

cyclin E1

CCNE1

-

No change

1.34

up

204855_at

serpin peptidase inhibitor, clade B (ovalbumin), member 5

SERPINB5 (Maspin)

-

No change

1.32

up

201110_s_at

thrombospondin 1

THBS1 (TSP1)

-

No change

1.32

up

211692_s_at

BCL2 binding component 3

BBC3 (PUMA)

-

No change

1.23

up