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Figure 2 | Molecular Cancer

Figure 2

From: Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line

Figure 2

Morphological effects of drug treatments. (A) Optical microscope images of TPC-1 cells before and after drug treatments. Cell spreading increased following RPI-1 treatment. Dasatinib treatment changed cellular morphology, characterized by a smaller appearance. (B) Confocal microscope images of TPC-1 cells before and after drug treatments. The cells were stained with phalloidin and DRAQ5. The actin cytoskeletal structure of the cells was modified following dasatinib treatment; the branching actin structures appeared to be thickened at the cell edges (white arrows). Confocal images (512 × 512 pixels) were obtained using a 60× oil immersion lens and were analyzed using ImagePro 6.3 software. Scale bars, 40 μm.

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Molecular Cancer

ISSN: 1476-4598