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Figure 7 | Molecular Cancer

Figure 7

From: Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line

Figure 7

Validation of identified proteins of interest. Immunoblot experiments confirming the proteomic selection of proteins sensitive to RPI-1, dasatinib, or both drugs. Anti-p-Tyr immunoaffinity-purified proteins from TPC-1 cells, alone or treated with RPI-1, dasatinib, or both, were resolved by 3-8% SDS-PAGE and immunoblotted with antibodies specific to MET, discoidin (DCDB2), EGFR, CTND1, EPHA2, PLCγ, DOK1, RET/PTC1, FAK1, MVP, and GIT1. Normalization of results was obtained by immunoblotting analysis of beta-actin (ACTB).

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Molecular Cancer

ISSN: 1476-4598