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Figure 9 | Molecular Cancer

Figure 9

From: Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line

Figure 9

Principal pathways involved in TPC-1 cell survival and proliferation. Schematic representation of the principal pathways involved in TPC-1 cell survival and proliferation. RPI-1 acts on RET/PTC, blocking phosphorylation of the downstream proteins Akt and Shc. Dasatinib acts on Src, causing changes in focal adhesion proteins and proliferation. After treatment with the combination of RPI-1 and dasatinib, STAT3 and ERK1/2 remained active, possibly contributing to cell survival.

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