Figure 7
From: An evolved ribosome-inactivating protein targets and kills human melanoma cells in vitro and in vivo
In vivo results following treatment regimens in SCID mice harboring established 518-A2 tumor xenografts. The regimens included 10-day, daily injections of a saline control (i.v) (white circles) or SLT-1AIYSNKLM (i.v. 0.5 mg/kg) (black circles), or a 5-day course of DTIC (i.p. 8 mg/kg) (white squares), or the combination of both SLT-1AIYSNKLM (i.v. 0.5 mg/kg) with DTIC (i.p. 8 mg/kg) regimens (black squares), (n = 7). (A) Mice showed no change in body weight related to treatment regimens over time. (B) Measured tumor volumes of mice demonstrate a significant synergistic effect of combining SLT-1AIYSNKLM and DTIC treatments when compared to either treatment alone or to the saline control (P < 0.0001). (C) Kaplan-Meier plot comparing animal survival as a function of treatment regimens (ten-day regimen; black bar).