Table 4 Seventy-eight reproducible differentially expressed genes induced by IGFBP-rP1 in RKO cells

[NM_004342] CALD1 (1, 1.4, 0.7) *

[NM_024496] C14orf4 (-0.3,0.1(NC),-0.3)

[NM_001457] FLNB (0.4,1.4,-0.3)

[NM_032883] C20orf100 (-0.8,-0.2(NC),-0.6)

[NM_018027] FRMD4A (0.5,0.6,0.5) *

[NM_001964] EGR1 (0.7,0.4,-0.1)

[NM_005556] KRT7 (-0.2,-0.3,-0.2 (NC**))

[NM_012081] ELL2,(0.2,-0.6,-1.1)

[NM_002273] KRT8(-0.7,-0.3 (NC),-1)

[NM_005252] FOS (1.1,0.6,-0.5)

[NM_002281] KRTHB1 (-3.8,0.7,-1.3)

[NM_017445] H2BFS (0.5,0.7,0)

[NM_002628] PFN2 (0.3,-0.7,-0.8)

[NM_080593] HIST1H2BK (0.5,0.6,-0.1(NC))

[NM_006950] SYN1 (-1.7,-1.5,-2.7) *

[NM_002165] ID1 (-1.2,-1.2,-1) *

[NM_001001522] TAGLN (1,1.6,0.6) *

[NM_002167] ID3 (-0.3(NC),-0.9,-0.7)

Extracellular related

[NM_014903] NAV3 (0.9,0.4,0.6) *

[NM_001657] AREG (-2.7,-1.6,-0.4) *

[NM_002135] NR4A1 (0.6,0.9,-0.6 (NC))

[NM_004406] DMBT1 (0.5,-1.4,-1)

[NM_006186] NR4A2 (0.4,1,-0.4)

[NM_006851] GLIPR1 (0.3,0.1,0)

[NM_003489] NRIP1 (-0.9,0.4, -0.3)

[NM_001553] IGFBP-rP1 (6.6,5.6,5.9) *

[NM_005902] SMAD3 (-0.5,0.1,-0.6)

[NM_003155] STC1 (-2.7,-3.8,-1.5) *

[NM_001005176] SP140 (1.1,1.3,0.6) *

[NM_003236] TGFA (-0.3, -0.5, -0.5)

[NM_006022] TSC22D1 (-0.3(NC), -0.6,-0.5)

[NM_003254] TIMP1 (-0.1(NC),-0.3, -0.6)

[NM_024836]ZNF672 (0.5,0.9,-0.1(NC))

[NM_003255] TIMP2 (-4.5,-0.3 (NC),-1)

Others

[NM_022164] TINAGL1 (-0.9,0.9,-0.4)

[NM_032744] C6orf105 (-5 (NC),-1.5,-2.3)

Cell proliferation and differentiation

[Hs.569345]C14orf34 (1.3,1.6,0.1(NC))

[NM_000700] ANNEXIN A1 (-1.8,-1.2.-0.5(NC))

[NM_005127] CLEC2B (0.9,1.3,0.4(NC))

[NM_004936] CDKN2B (-0.8,-1.7, -0.8) *

[NM_001004023] DYRK3 (0.8,0.9,-0.3(NC))

[NM_018482] DDEF1 (0.3,0.6,0.1(NC))

[NM_001008493] ENAH (0.4,0.4,0.1(NC))

[NM_015675] GADD45B (1.1,0.8,0.2 (NC))

[NM_001005915] ERBB3 (-0.8,0.2(NC),-0.4)

[NM_003641] IFITM1(-0.7,-1.5,-0.4 (NC))

[NM_005330] HBE1 (4.3,-4.6,-1.5)

[NM_001025242] IRAK1 (-0.6 (NC), -1.5,-0.6)

[NM_005525] HSD11B1 (-3.1,-1.1,1.7)

[NM_014330] PPP1R15A (0.7,0.5, -0.2)

[NM_203434] IER5L (-0.7,-0.7,-0.7) *

[NM_173354] SNF1LK (-0.5,-0.2,0.5)

[NM_005544] IRS1 (-1.4,-0.7,-0.9) *

[NM_000346] SOX9 (-1.9,-1.5,-1.1) *

[NM_002288] LAIR2 (-0.9,-1.3,0.4)

[NM_002354] TACSTD1 (-0.7,-1.4,-1.9) *

[NM_002291] LAMB1 (-1.1,-0.6,-1) *

Enzyme regulated

[NM_006669] LILRB1(-1.5,-1.2,-0.1 (NC))

[NM_004753] DHRS3 (-2.4,0.1 (NC),-1.6)

[NM_021070] LTBP3 (-1.1,0.5(NC),-0.6)

[NM_001005336] DNM1 (-0.6,-0.4,-0.3(NC))

[NM_138794] LYPLAL1 (0.4,0.4,-0.3(NC))

[NM_005261] GEM (0.8,0.5,0.1 (NC))

[NM_024979] MCF2L (-0.1(NC),-2.6,-3.8)

[NM_015590] GPATCH4 (0.3,0.4,-0.1(NC))

[NM_006818] MLLT11 (1,-1.4,-1)

[NM_003979] GPRC5A (-1.2,-0.1,-0.7)

[NM_176870] MT1K (-0.5,-0.2(NC),-0.6)

[NM_004637] RAB7 (0.5,0.5,-0.2)

[NM_000271] NPC1 (0.6,0.8,0.1)

[NM_002890] RASA1 (0.3,-0.4,-0.5)

[NM_002599] PDE2A (-2(NC),-1.7,-2.4)

[NM_007211] RASSF8 (0.4(MI***),1.9,2.5)

[NM_018444] PPM2C (-0.6,-0.5,0.2(NC))

[NM_005168] RND3 (1,0.7, 0.1(NC))

[NM_004155] SERPINB9 (-0.6,0.3 (NC),-0.9)

[NM_005415] SLC20A1 (0.2(NC), -0.3,-0.5)

[NM_003364] UPP1(0.4,1,0.1(NC))