Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection

Table 3 Comparative analysis of studies examining expression of STAT3 and phosphorylated STAT3 in cervical precancer and cancerous lesions

Study (Year)	Tissues		Type of study	Immunohistochemistry (% positivity)			Immunoblotting (% positivity)			STAT3 DNA Binding	Correlation with HPV positivity
	Precancer (n)	Cancer (n)		STAT3	pSTAT3 (Y705)	pSTAT3 (S727)	STAT3	pSTAT3 (Y705)	pSTAT3 (S727)
Yang et al. (2005)	56	-	Retrospective	ND	ND	42% (24/56)^a	ND	ND	ND	ND	ND
Yang et al. (2006)	56	-	Retrospective	39% (22/56)^a	ND	ND	ND	ND	ND	ND	ND
Chen et al. (2007)	-	104	Retrospective	ND	24% (25/104)^b	23% (24/104)^b	ND	ND	ND	ND	ND
Takemoto et al. (2009)	-	125	Retrospective	ND	57% (71/125)^b	ND	ND	ND	ND	ND	ND
Shukla et al. (present study)	30	70	Prospective	25% (5/20) ^a 71% (30/50) ^b	20% (4/20) ^a 56% (28/50) ^b	10% (2/20) ^a 40% (20/50) ^b	40% (12/30) ^a 71% (50/70) ^b	33% (10/30) ^a 57% (40/70) ^b	33% (10/30) ^a 45% (32/70) ^b	Yes	Yes

ISSN: 1476-4598