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Table 3 Comparative analysis of studies examining expression of STAT3 and phosphorylated STAT3 in cervical precancer and cancerous lesions

From: Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection

Study (Year) Tissues Type of study Immunohistochemistry
(% positivity)
Immunoblotting
(% positivity)
STAT3 DNA Binding Correlation with HPV positivity
  Precancer (n) Cancer (n)   STAT3 pSTAT3 (Y705) pSTAT3 (S727) STAT3 pSTAT3 (Y705) pSTAT3 (S727)   
Yang et al. (2005) 56 - Retrospective ND ND 42% (24/56)a ND ND ND ND ND
Yang et al. (2006) 56 - Retrospective 39% (22/56)a ND ND ND ND ND ND ND
Chen et al. (2007) - 104 Retrospective ND 24% (25/104)b 23% (24/104)b ND ND ND ND ND
Takemoto et al. (2009) - 125 Retrospective ND 57% (71/125)b ND ND ND ND ND ND
Shukla et al. (present study) 30 70 Prospective 25% (5/20) a
71% (30/50) b
20%
(4/20) a
56% (28/50) b
10%
(2/20) a
40% (20/50) b
40%
(12/30) a
71%
(50/70) b
33% (10/30) a
57% (40/70) b
33% (10/30) a
45% (32/70) b
Yes Yes
  1. aPrecancer tissues, bCancer tissues; ND - not determined.