Table 3 Comparative analysis of studies examining expression of STAT3 and phosphorylated STAT3 in cervical precancer and cancerous lesions
| Study (Year) | Tissues | Type of study |
Immunohistochemistry (% positivity) |
Immunoblotting (% positivity) | STAT3 DNA Binding | Correlation with HPV positivity | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Precancer (n) | Cancer (n) | STAT3 | pSTAT3 (Y705) | pSTAT3 (S727) | STAT3 | pSTAT3 (Y705) | pSTAT3 (S727) | ||||
| Yang et al. (2005) | 56 | - | Retrospective | ND | ND | 42% (24/56)a | ND | ND | ND | ND | ND |
| Yang et al. (2006) | 56 | - | Retrospective | 39% (22/56)a | ND | ND | ND | ND | ND | ND | ND |
| Chen et al. (2007) | - | 104 | Retrospective | ND | 24% (25/104)b | 23% (24/104)b | ND | ND | ND | ND | ND |
| Takemoto et al. (2009) | - | 125 | Retrospective | ND | 57% (71/125)b | ND | ND | ND | ND | ND | ND |
| Shukla et al. (present study) | 30 | 70 | Prospective |
25% (5/20)
a
71% (30/50) b |
20%
(4/20) a 56% (28/50) b |
10%
(2/20) a 40% (20/50) b |
40%
(12/30) a 71% (50/70) b |
33% (10/30)
a
57% (40/70) b |
33% (10/30)
a
45% (32/70) b | Yes | Yes |