Table 1 Top ranked GSEA gene sets from the C2 database (curated pathways) associated with MLL expression profiles in T-ALL cell lines.
Gene Set | Description of Biological Pathway | FDR * |
|---|---|---|
Electron_transport_chain | Electron transport chain | 0.137 |
Glycolysis_gluconeogenesis | Glycolysis and gluconeogenesis | 0.142 |
Peng_leucine_down | Down-regulated in response to leucine starvation | 0.145 |
RNA_transcription_reactome | RNA transcription reactome | 0.145 |
Mitochondria | Mitochondrial genes | 0.148 |
Aminoacyl_tRNA_biosynthesis | Amino-acyl tRNA biosynthesis | 0.151 |
Human_mitodb_6_2002 | Mitochondrial genes | 0.152 |
Hdaci_colon_cur24hrs_up | Genes upregulated by curcumin, transcription inhibitor | 0.156 |
Hdaci_colon_cur48hrs_up | Genes upregulated by curcumin, transcription inhibitor | 0.163 |
Myc_huvec_sage_array_up | Genes up-regulated by myc | 0.176 |
Peng_rapamycin_down | Down-regulated in response to rapamycin | 0.183 |
Oxidative_phosphorylation | Oxidative phosphorylation | 0.190 |
tRNA_synthetases | tRNA synthetases | 0.192 |
Proteasome_pathway | Proteasomal pathway genes | 0.200 |
Peng_glutamine_down | Down-regulated in response to glutamine starvation | 0.203 |
Krebs_TCA_cycle | Krebs (TCA) cycle genes | 0.204 |
Proteasome | Proteasome genes | 0.238 |