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Table 2 Top ranked GSEA gene sets from the C4 database (computed gene networks) associated with MLL expression profiles in T-ALL cell lines.

From: Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia

Gene Set

Description of Network Hub Genes and Associated Functions

FDR *

MORF_PRDX3

Peroxiredoxin 3 - MYC-mediated proliferation, glucose responses

0.132

MORF_SOD1

Superoxide dismutase 1 - mitochondria, oxidative metabolism

0.135

MORF_MAP2K2

MAP2K2 - ERK, JNK, p38, NFkB, and apoptosis pathways

0.138

MORF_PTPN11

Protein tyrosine phosphatase, cell growth, differentiation, metabolism

0.140

GNF2_RAN

RAS oncogene family - cell cycle, mitotic spindle regulation

0.143

MORF_GMPS

Guanine monphosphate synthetase - purine synthesis, cell cycle

0.146

MORF_DEAF1

DEAF1 or supressin, inhibitor of proliferation

0.152

MORF_ERH

Enhancer of rudimentary homolog - cell cycle regulator

0.155

GNF2_NS

Nucleostemin - cell cycle progression in stem cells, links with p53

0.158

MORF_GPX4

Glutathione peroxidase 4 - cellular antioxidant defence

0.159

MORF_AATF

Apoptosis antagonizing transcription factor

0.160

MORF_EIF3S2

EIF3S2 - eukaryotic translation initiation factor

0.164

MORF_ATOX1

ATX1 antioxidant protein 1 homolog - antioxidant defense

0.165

MORF_EI24

Etoposide induced mRNA - early p53 response gene

0.166

MORF_PSMC1

Proteasome 26S subunit, ATPase

0.173

MORF_RAN

RAS oncogene family - cell cycle, mitotic spindle regulation

0.179

MORF_RAB5A

Ras-associated protein - exocytosis, actin organisation

0.180

MORF_UNG

Uracil-DNA glycosylase - base-excision DNA repair pathway

0.182

MORF_FBL

Fibrillarin - component of snRNP synthesis of ribosomal RNA

0.203

GCM_MAX

Myc-associated factor X - transcriptional regulator

0.224

  1. * FDR, false discovery rate; GSEA cutoff for significance FDR <0.25