Figure 2

Quantification of ADP-ribose polymer adducts in cancer patients. (a) The graph shows the levels of ADP-ribose polymer of PBL proteins of each subject as a dot for cancers of different sites in the head and neck region (grouped as cancer of H & N) as compared to all controls (dark green - female (n = 27); light green - male (n = 41)). In all, 14 different types of cancers of H & N were examined in this study; for three such cancers we had only one patient each. Individually all cancers of different sites under H & N category declined significantly below the control value (see details in Table 1). The results from patients with cancers of breast and cervix have been shown in (b) and (c), respectively. Since these two cancers exclusively afflict females, the plot shows individual values of total ADP-ribose polymer of PBL proteins for all controls (males + females) as well as only female controls. In all three categories of cancers, the reduction in the level of total ADP-ribose polymer of PBL proteins was highly significant (P < 0.0001) when compared with all controls or only female controls (inset Table).