Functional analysis of genes significantly up-regulated in R2N1d cells compared with R2d cells. A, genes involved in top ten of GeneGo pathway maps and top ten GeneGo process networks by MetaCore analysis. B, number of up-regulated genes belongs to 5 functional categories. Eight genes are at once correlated with metastasis, inflammation and angiogenesis, i.e. TNFRSF12A, CEACAM1, PLAU, HIF1A, IL8, HMOX1, VEGFC and IL1B, whereas two genes are correlated with adhesion, metastasis, and migration, i.e. CD44 and LAMC1.