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Table 1 Comparison of fold increase of RNA transcript between R2N1d and R2d cells by qPCR analysis

From: Increasing CD44+/CD24- tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesis

Gene Name

Symbol

Description

Up-/Down-Regulation

AACT/ACT

SERPINA3

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

12.50

HER2/HER2

ERBB2

V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

6.38

ASBABP2/DIPLA1

PAPPA

Pregnancy-associated plasma protein A, pappalysin 1

3.91

AIS/DHTR

AR

Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)

3.50

TSP2

THBS2

Thrombospondin 2

3.30

CORNIFIN/GADD33

SPRR1B

Small proline-rich protein 1B (cornifin)

3.14

COX-2/COX2

PTGS2

Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

2.59

IBP2/IGF-BP53

IGFBP2

Insulin-like growth factor binding protein 2, 36kDa

2.49

CD271/Gp80-LNGFR

NGFR

Nerve growth factor receptor (TNFR superfamily, member 16)

2.41

Cyclin A1

CCNA1

Cyclin A1

2.36

ARMD9/ASP

C3

Complement component 3

2.22

BCEI/D21S21

TFF1

Trefoil factor 1

2.13

STC-2/STCRP

STC2

Stanniocalcin 2

-2.21

BAG-1

BAG1

BCL2-associated athanogene

-2.34

GIG8/ID2A

ID2

Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

-2.48

DKFZp686A04236/HMG1

HMGB1

High-mobility group box 1

-2.54

CD49f/ITGA6B

ITGA6

Integrin, alpha 6

-2.56

DKFZp686N23123/ER

ESR1

Estrogen receptor 1

-2.64

Beta-NGF/HSAN5

NGF

Nerve growth factor (beta polypeptide)

-2.68

GIF/GIFB

MT3

Metallothionein 3

-3.88

CBF-A/CBF-B

NFYB

Nuclear transcription factor Y, beta

-4.04