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Figure 2 | Molecular Cancer

Figure 2

From: Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells

Figure 2

Expression of RGS10 and RGS17 transcripts is acutely and persistently downregulated in response to cisplatin exposure. SKOV-3 cells were treated with vehicle or the IC80 dose (100 μM) of cisplatin for 48 hours. RNA was isolated from the cells either immediately (black bars), or after an additional subsequent 48 hour incubation in fresh media, in the absence of drug (striped bars). The expression of RGS10 and RGS17 transcripts was normalized to GAPDH internal standards. The fold change in expression relative to vehicle controls was calculated by the 2-ΔΔCt method. *p < 0.05, vehicle treated vs. cisplatin treated.

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